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Phytochemical Details

01. General Information

02. Source Information of Phytochemical

Oenothera biennis Warm

Chineses Pinyin	YueJianHua
Use Part	Seed
Flavor	Sweet; Bitter
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Myrtales 　　　　-->Family: Onagraceae 　　　　　-->Genus: Oenothera 　　　　　　-->Species: Oenothera biennis

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 604

Ref_1

Pair Name	Evening primrose oil, Tamoxifen
Partner Name	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Tumor angiogenesis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	The most significant finding of this study was the confirmation of the anticancer activity of the natural product EPO, which potentiated the activity of the anticancer drug TAM against MCF-7 and MDA-MB-231 BC cell lines through the induction of apoptosis, inhibiting angiogenesis and halting cell proliferation.

04. Reference

No.	Title	Href
1	Evening Primrose Oil Enhances Tamoxifen's Anticancer Activity against Breast Cancer Cells by Inducing Apoptosis, Inhibiting Angiogenesis, and Arresting the Cell Cycle. Molecules. 2022 Apr 7;27(8):2391. doi: 10.3390/molecules27082391	`Click`